Loh, M.L.

mutation leukemia bcl 11a blood protein myeloid patient myelomonocytic leukemia cbl mutations cancer number expression growth figure sample university analysis myelomonocytic tumor marrow insertion identi fied children mouse assay .371y identi department syndrome hematopoietic factor 21cip function table study subject germline antibody volume disease cbl mutation hematopoietic cells myeloid leukemia ficiency bcl 11a overexpression transduced pathway leukemogenesi p .371y allele group neuro bone marrow cells ligase m.l.l nf 1 loss − − nature level control colony malignancy ptpn 11 proviral insertions bone marrow result development evi 9 insertions germline cbl mutations splice cause bcl 11a expression proviral pediatrics san francisco noonan domain vector suppressor noonan syndrome