Lang, A.E.

patient mutation disease lrrk 2 parkinsonism neurology 2019ser journal supranuclear palsy tauopathie study idiopathic pd parkinson symptom research pathology idiopathic onset protein dementia supranuclear disorder brain model neuro fibrillary tangles palsy lrrk 2-associated pd treatment microtubule centre musculu cause scale university frequency phenotype carrier tauopathy atrophy european syndrome tangle family kinase neuro department estimate state gsk -3 activity penetrance neuron table motor ó 2009 frontotemporal trial stage frontotemporal dementia qsbb series consortium author group lrrk 2 mutations series hospital hyperphosphorylation institute tau pathology tau hyperphosphorylation 10 years fibrillary fference diagnosis 297–309 science criteria alzheimer compilation london degeneration