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study association control longevity methylation effect analysis allele disease folic replication table rs 2075650 leiden mitochondrial garp study linkage rotterdam netherland cohort university rs 429358 folic acid sample periconceptional leiden 85- subject result genome-wide sibling genet model center rotterdam study locus diabetes variant haplotype level signi birth weight susceptibility protein danish child serum birth p-value survival erasmus university rotterdam genotype igf 2 dmr dna methylation type 2 diabetes research population apoe locus osteoarthritis 85- rs 225014 nonagenarian growth leiden longevity study danish 1905 cohort rs gwas controls family ficant t 2dm sibling pairs mother folic acid use igf 2 methylation stage leiden university rs 7412 health difference polymorphism offspring defect
4 Most Recent Publications
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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
(Article)
Deelen, J. Beekman, M. Akker, E.B. van den Passtoors, W.M. Tiemeier, H. Heemst, D. van de Craen, A.J.M. Rivadeneira Ramirez, F. Geus, E.J.C. de Perola, M. Ouderaa, F.J. van der Gunn, D.A. Uh, H.-W. Boomsma, D.I. Uitterlinden, A.G. Christensen, K. Tikka-Kleemola, P. Heijmans, B.T. Houwing-Duistermaat, J.J. Westendorp, R.G.J. Slagboom, P.E. Helmer, Q. Kuningas, M. Christiansen, L. Kremer, D. Breggen, R. van der Suchiman, H.E.D. Lakenberg, N. |
2011-08-01
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Periconceptional maternal folic acid use of 400 μg per day is related to increased methylation of the IGF2 gene in the very young child
(Article)
Steegers-Theunissen, R.P.M. Obermann-Borst, S.A. Kremer, D. Lindemans, J. Siebel, C. Slagboom, P.E. Heijman, B.T. |
2009-11-16
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Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study
(Article)
Reiling, E. Vliet-Ostaptchouk, J.V. van Smit, J.W.A. Nijpels, M.G.A.A.M. Heine, R.J. Uitterlinden, A.G. Pedersen, O. Slagboom, P.E. Maassen, J.A. Hofker, M.A. Hart, L.M. 't Dekker, J.M. Riet, E. van 't Haeften, T.W. van Arp, P.P. Hansen, T. Kremer, D. Groenewoud, M.J. Hove, E.C. van Romijn, J.A. |
2009-02-12
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Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis
(Article)
Meulenbelt, I. Min, J. Meurs, J.B.J. van Deure, W.M. van der Visser, T.J. Seymour, A.B. Lakenberg, N. Breggen, R. van der Kremer, D. Tikka-Kleemola, P. Kloppenburg, M. Loughlin, J. Bos, S.D. Slagboom, P.E. Riyazi, N. Houwing-Duistermaat, J.J. wijk, H.J. van der Kroon, H.M. Nakajima, M. Ikegawa, S. Uitterlinden, A.G. |
2008-06-15
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