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expression development thymocyte level vector therapy lentiviral number analysis figure blood rearrangement ficiency stage catenin t-cell wnt 3a transplantation gene therapy t cell development b cells protein target t-cell development leukemia wnt target genes subset experiment il 2rg result mouse wnt 3a embryos factor t cells transduction - catenin thymu thymic promoter immunol fl ow cytometry spleen sffv.corag study patient b-cell differentiation btk à/à mice serum percentage lentiviral vectors transduced lmo 2 transcription embryo proliferation cd 34 thymocytes lineage rag 1 expression target genes hematopoietic microarray control 1-/- myeloid signal animal assay immunode probe insertional mutagenesis defect rq-pcr reconstitution ficiency yy ng kinase transfer murine treatment gene expression
8 Most Recent Publications
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Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer
(Article)
Pike-Overzet, K. Rodijk, M. Bredius, R.G.M. Driessen, G.J.A. Thrasher, A.J. Baum, J.A.C. Cavazzana-Calvo, M. Dongen, J.J.M. van Staal, F.J.T. Ng, Y.Y. Baert, M.R. Lagresle-Peyrou, C. Schambach, A. Zhang, F. Hoeben, R.C. Hacein-Bey-Abina, S. Lankester, A.C. |
2011-09-01
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Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK
(Article)
Ng, Y.Y. Baert, M.R. Pike-Overzet, K. Rodijk, M. Brugman, M.H. Schambach, A. Hendriks, R.W. Dongen, J.J.M. van Staal, F.J.T. |
2010-09-01
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Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
(Article)
Luis, T.C. Weerkamp, F. Naber, B.A. Baert, M.R. Haas, E.F. de Nikolic, T. Heuvelmans, S. Krijger, R.R. de Dongen, J.J.M. van Staal, F.J.T. |
2009-01-15
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Isolation of human and mouse hematopoietic stem cells.
(Article)
Ng, Y.Y. Baert, M.R. Haas, E.F. de Pike-Overzet, K. Staal, F.J.T. |
2009-01-01
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Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: Implications for leukemogenesis in gene therapy
(Article)
Pike-Overzet, K. Ridder, D. de Dongen, J.J.M. van Staal, F.J.T. Weerkamp, F. Baert, M.R. Verstegen, M.M.A. Brugman, M.H. Howe, S.J. Reinders, M.J.T. Thrasher, A.J. Wagemaker, G. |
2007-04-01
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Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules.
(Article)
Weerkamp, F. Baert, M.R. Naber, B.A. Koster, E.E. Haas, E.F. de Atkuri, K.R. Dongen, J.J.M. van Herzenberg, L.A. Staal, F.J.T. |
2006-02-28
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New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
(Article)
Dik, W.A. Dongen, J.J.M. van Spek, P.J. van der Pike-Overzet, K. Staal, F.J.T. Langerak, A.W. Weerkamp, F. Ridder, D. de Haas, E.F. de Baert, M.R. Koster, E.E. Reinders, M.J. |
2005-01-01
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Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion
(Article)
Staal, F.J.T. Weerkamp, F. Baert, M.R. Burg, C.M. van den Noort, M. van Haas, E.F. de Dongen, J.J.M. van |
2004-01-01
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