Meijer, H.P.

crypt control villu intestine epithelial goblet expression goblet cells damage mtx treatment days 1 paneth cells paneth proliferation treatment villus atrophy colon number enterocyte mtx-induced days 3 jejunum region villi section muc 2-positive cells day 4 regeneration villus tips atrophy lysozyme days 5 mtx-treated rats epithelium ileum merck crypt damage epithelial cells muc 2 duodenum apoptosi level factor body weight day 2 epithelial proliferation mtx-treated crypt depth mtx-induced villus atrophy animal control levels mrna expression staining physiol epithelial damage study tff 3 effect p 0.05 vs methotrexate differentiation depth boehringer length change weight villus height mtx-induced damage villus enterocytes function control values marker day 1 activity epithelial defense crypt-villus axis epithelial cell types trefoil 2-positive crypt-villu