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study digoxin effect genotype rotterdam study interval variant association rotterdam heart population haplotype allele participant qtc interval subject nos 1ap heart failure result death reference digoxin users concentration model patient cohort nos 1ap variants analyses serum number analysis table qt interval prolongation mortality failure polymorphism duration sulfonylurea abcb 1 qtc prolongation disease nos 1ap gene difference baseline women abcb 1 variants digoxin intoxication group diabetes infarction mefloquine admission factor research channel study population follow-up intoxication increase gg genotype nitric oxide frequency chapter diabetes mellitus variation digoxin dose pharmacol function prescription nitric oxide synthase glibenclamide circulation 3435t heart disease genotyped abcb 1 snps ratio clin pharmacol
10 Most Recent Publications
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Genetic variation in NOS1AP is associated with sudden cardiac death: Evidence from the Rotterdam Study
(Article)
Eijgelsheim, M. Newton-Cheh, C. Aarnoudse, A.-J.L.H.J. Noord, C. van Witteman, J.C.M. Hofman, A. Uitterlinden, A.G. Stricker, B.H.Ch. |
2009-10-20
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Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation
(Article)
Noord, C. van Aarnoudse, A.-J.L.H.J. Eijgelsheim, M. Sturkenboom, M.C.J.M. Straus, S.M. Hofman, A. Kors, J.A. Newton-Cheh, C. Witteman, J.C.M. Stricker, B.H.Ch. |
2009-04-01
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C-reactive protein levels, haplotypes, and the risk of incident chronic obstructive pulmonary disease
(Article)
Durme, Y.M.T.A. van Verhamme, K. Aarnoudse, A.-J.L.H.J. Pottelberge, G.R. van Hofman, A. Witteman, J.C.M. Joos, G.F. Brusselle, G.G. Stricker, B.H.Ch. |
2009-03-01
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Psychotropic drugs associated with corrected QT interval prolongation
(Article)
Noord, C. van Straus, S.M. Sturkenboom, M.C.J.M. Hofman, A. Aarnoudse, A.-J.L.H.J. Bagnardi, V. Kors, J.A. Newton-Cheh, C. Witteman, J.C.M. Stricker, B.H.Ch. |
2009-02-01
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Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration
(Article)
Eijgelsheim, M. Aarnoudse, A.-J.L.H.J. Rivadeneira Ramirez, F. Kors, J.A. Witteman, J.C.M. Hofman, A. Tikka-Kleemola, P. Uitterlinden, A.G. Stricker, B.H.Ch. |
2009-01-05
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Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea
(Article)
Becker, M.L. Aarnoudse, A.-J.L.H.J. Newton-Cheh, C. Hofman, A. Witteman, J.C.M. Uitterlinden, A.G. Visser, L.E. Stricker, B.H.Ch. |
2008-07-01
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Genetic susceptibility to adverse drug effects : common variants in the ABCB1 and NOS1AP genes
(Doctoral Thesis)
Aarnoudse, A.-J.L.H.J. |
2008-04-09
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Adverse drug reaction-related hospitalisations: A population-based cohort study
(Article)
Hooft, C.S. van der Dieleman, J.P. Siemes, C. Aarnoudse, A.-J.L.H.J. Verhamme, K. Strieker, B.H.C.H. Sturkenboom, M.C.J.M. |
2008-04-01
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Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration
(Article)
Aarnoudse, A.-J.L.H.J. Dieleman, J.P. Visser, L.E. Arp, P.P. Heiden, I.P. van der Schaik, R.H.N. van Molokhia, M. Hofman, A. Uitterlinden, A.G. Stricker, B.H.Ch. |
2008-04-01
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Common NOS1AP variants are associated with a prolonged QTc interval in the rotterdam study
(Article)
Aarnoudse, A.-J.L.H.J. Newton-Cheh, C. Bakker, P.I.W. de Straus, S.M. Kors, J.A. Hofman, A. Uitterlinden, A.G. Witteman, J.C.M. Stricker, B.H.Ch. |
2007-07-01
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