Beishuizen, A.

leukemia rearrangement patient precursor lymphoblastic leukemia relapse childhood lymphoblastic study analysis probe diagnosis children blood disease b-all precursor b-all region group receptor cancer detection table treatment segment immunoglobulin parent deletion chain result junctional figure marker b-cell precursor 8- junctional regions t-all expression sample t-cell pattern van dongen jjm antigen chromosome mastocytosi change kde rearrangements child chapter surgery polymerase chain reaction blot analysis restriction sequence difference tcr genes score clonal dongen germline lymphoma tcr-o differentiation technique leukemic translocation tcr gene rearrangements subclone shift activity marrow level allele marker analysis leukaemia reaction frequency subclone formation netherland cytogenetic