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insulin activation study diabetes -1\erk kinase type 2 diabetes subject glucose secretion igf-i activity erk -1\erk activation netherland erk -1\erk variant insulin secretion intestine 407 cells glucose-stimulated insulin secretion table protein medium cohort efflux result association hypotonic igf-ii phosphorylation polymorphism type 2 hypotonicity-induced population genotype receptor -1/erk center control intestine osmosensitive level growth analysis 5 min erk -1/erk group ptdins 3- kinase lars 2 gene erk -1\erk activity stimulation mitochondrial increase insulin sensitivity allele map kinase family osmosensitive anion efflux enzyme pretreatment pathway glucose-stimulated dutch factor fasting germany ptdin sample 192- bp allele figure culture van der wijk odds ratio ras \erk cascade addition rasn 17 gene variants glucose tolerance glucose tolerance test hyperglycemic clamps sensitivity igf-ii gene variant
6 Most Recent Publications
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The association of mitochondrial content with prevalent and incident type 2 diabetes
(Article)
Reiling, E. Ling, C. Maassen, J.A. Geus, E.J.C. de Boomsma, D.I. Dekker, J.M. Groop, L. Willemsen, G.A.H.M. Hart, L.M. 't Uitterlinden, A.G. Riet, E. van 't Welschen, L.M.C. Ladenvall, C. Almgren, P. Lyssenko, V. Nijpels, M.G.A.A.M. Hove, E.C. van |
2010-04-01
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Genetic association analysis of LARS2 with type 2 diabetes
(Article)
Reiling, E. Jafar-Mohammadi, B. Nijpels, M.G.A.A.M. Groenewoud, M.J. Hove, E.C. van Uitterlinden, A.G. Smit, J.W.A. Morris, A.D. Doney, A.S.F. Palmer, C.N.A. Guiducci, C. Hattersley, A.T. Riet, E. van 't Frayling, T.M. Pedersen, O. Slagboom, P.E. Altshuler, D. Groop, L. Romijn, J.A. Maassen, J.A. Hofker, M.A. Dekker, J.M. McCarthy, M.I. Weedon, M.N. Hart, L.M. 't Vliet-Ostaptchouk, J.V. van Hansen, T. Saxena, R. Haeften, T.W. van Arp, P.P. Das, S. |
2010-01-01
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Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study
(Article)
Reiling, E. Vliet-Ostaptchouk, J.V. van Smit, J.W.A. Nijpels, M.G.A.A.M. Heine, R.J. Uitterlinden, A.G. Pedersen, O. Slagboom, P.E. Maassen, J.A. Hofker, M.A. Hart, L.M. 't Dekker, J.M. Riet, E. van 't Haeften, T.W. van Arp, P.P. Hansen, T. Kremer, D. Groenewoud, M.J. Hove, E.C. van Romijn, J.A. |
2009-02-12
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Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene
(Article)
Hart, L.M. 't Pols, H.A.P. Uitterlinden, A.G. Jorgensen, T. Duijn, C.M. van Borch-Johnsen, K. Pedersen, O. Hansen, T. Rietveld, I. Dekker, J.M. Maassen, J.A. Nijpels, M.G.A.A.M. Janssen, G.M. Arp, P.P. Heine, R.J. |
2005-01-01
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Genetic factors and insulin secretion: gene variants in the IGF genes
(Article)
Hart, L.M. 't Fritsche, A. Maassen, J.A. Haeften, T.W. van Rietveld, I. Dekker, J.M. Nijpels, M.G.A.A.M. Machicao, F. Stumvoll, M. Duijn, C.M. van Haring, H.U. Heine, R.J. |
2004-01-01
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Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway
(Article)
Wijk, Th. van der Dorrestijn, J. Narumiya, S. Maassen, J.A. Jonge, H.R. de Tilly, B.C. |
1998-01-01
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