Meur, Y. le

patient transplantation study transplant exposure mpa exposure concentration mycophenolate mofetil mycophenolate mycophenolic acid rejection group mycophenolic recipient mofetil tacrolimu pharmacokinetic transplant recipients polymorphism impdh month drug monitoring target mpa auc 0–12 therapy monitoring liver effect outcome cyclosporine university department analysis relationship mpa auc 0 time points range value kidney table trial result trough dosing 0–12 plasma treatment point mycophenolic acid exposure sample roche oellerich m concentration –time curve hospital nephrology -2152 -275 randomized association difference allele incidence armstrong vw nephrol promoter method mpa concentrations efficacy day 3 mpa pharmacokinetics fixed-dose carrier level assay gelder impdh ii gene 12 hours strategy dosage metabolite