Mamelok, R.

patient transplantation tacrolimu study concentration transplant rejection exposure pharmacokinetic group month mycophenolic acid cyp 3a transplant recipients model cyp 3a genotype mycophenolic mycophenolate mofetil recipient polymorphism mycophenolate mpa-auc 0 –12 mofetil mpa exposure day 3 genotype cyp 3a expressers analysis value effect population mpa auc 0–12 difference drug monitoring mpa cl incidence table therapy hoffmann-la roche ltd kidney predose mpa-auc result cyp 3a nonexpressers covariate cyclosporine cyp 3a allele fi nal model target relationship variability fixed-dose clearance monitoring pharmacol treatment department nonexpresser allele time points university concentration –time curve roche –12 -2152 gelder -275 time-dependent 0–12 creatinine clearance center transplant patients mpa concentrations expresser mpa pharmacokinetics mycophenolic acid exposure equation change time-dependent cl number