Linden, E. van der

protein rad 50 binding mre 11 complex relapse domain repair atpase patient analysis diagnosis interaction leukemia nbs 1 dna binding function sample activity expression probe rad 50 complexes probe sets lymphoblastic leukemia precursor-b-all t-all study volume atp binding gene expression change double-strand diagnosis –relapse samples figure hopfner number cluster lymphoblastic atpase domains erasmus university rotterdam cycle stoichiometry cohesin preparation architecture fication dna-binding globular dna tethering mechanism dna double-strand group difference paull hirano wyman microarray association hydrolysis differentially break tethering acids research dimeric dsb repair structure identi leukemic clone nuclease chromosome jager component activation –relapse pathway 2001 b motif atp hydrolysis fjt staal