Velthuis, J.H.L.

patient t cells t-cell transplantation 25bright rejection transplant level expression function foxp 3 cd 25bright cells islet study response kidney epitope blood proliferation recipient number donor immunol allograft control month analysis diabetes il -2 rapamycin grade hla-a sample tolerance capacity table kidney transplant recipients tacrolimu frequency type 1 diabetes depletion suppressive control subjects result mrna levels biopsy presence insulin speci cd 4ϩcd cells il -2 production subject erasmus mc monotherapy effect responder difference donor-specific marker graft treatment islet cell transplantation 3 rd party-antigens 25neg cd 4ϩcd cd 25 ishlt suppressive capacity reactivity party recent-onset party-ag mrna expression levels donor-ag induction increase autoreactive blood samples monotherapy rapamycin proliferative response