Sombogaard, F.

impdh impdh activity activity patient concentration transplantation transplant study sample level mycophenolate mofetil dehydrogenase monophosphate mycophenolate mycophenolic acid mycophenolic inosine mofetil method assay transplant recipients recipient impdh type i expression plasma blood pharmacokinetic therapy value monitoring variability enzyme mpa concentrations correlation mpa concentration pharmacodynamic rejection chapter transplant patients group polymorphism protein albumin model effect difference day 6 van gelder t kidney inhibition table impdh activity assay outcome result impdh type ii impdh mrna levels mpa cl glander hsct patients mpa auc figure visit monit variant parameter determination mmf therapy kidney transplantation hambach p activiteit impdh type 1 ic 50 curve relationship netherland gelder inter-patient variability analysis pharmacol patien