Destici, E.

circadian clock circadian clock cycle expression phase control damage protein cell cycle rhythm 1‑/- |cry period figure microrna science oscillator dna damage cry 2-/- mice analysis level response transcription radiation proliferation mutation tissue mouse dna damage response animal study oscillation cell cycle progression culture exposure liver circadian gene expression chapter genotoxic experiment 1-/-|cry mechanism effect activity van der horst cry 1-/-|cry mefs fibroblast cry 1 pathway process treatment circadian rhythms cancer resetting feedback light system circadian oscillator result advance 2-/- horst circadian oscillations nature bmal 1 cry 1-/- factor kinase circadian system /bmal progression schibler difference survival 1-/- condition error bars cry 2 proliferation rate example