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women study atherosclerosi level disease aortic aortic atherosclerosis association factor insulin menopause postmenopausal cholesterol hormone postmenopausal women progression calcification result risk factors subject effect smoking subclinical hypothyroidism blood therapy aortic calcification hormone replacement therapy serum follow-up baseline population body mass index insulin resistance pressure insulin resistance syndrome carotid resistance infarction rotterdam study hypothyroidism table rotterdam testosterone heart diabetes subclinical participant androgen estrogen homocysteine diabetes mellitus increase artery systolic blood pressure heart disease replacement health thyroid index disease risk factors research mellitu analysis chapter tertile inflammation value plasma syndrome postmenopausal hormone use premenopausal sample analyses ratio weight stroke cholesterol level difference adhesion molecules protein