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pre-b b cells expression slp -65 -65 pre-b cells tumor b cell development kinase chain development figure protein activation migration immunol pre-bcr tyrosine patient btk /slp b-cell tyrosine kinase level rearrangement syndrome differentiation receptor function result suppressor btk-deficient stage immunity e 41k il -7 pro-b mutation bruton defect leukemia chapter tumor suppressor absence antibody activity recombination phosphorylation surface pathway pre-b cell stage presence pro-b cells mouse response control dt 40 cells ficient k 430r lymphoma pre-b cell tumors signal adhesion proliferation btk-deficient mice pre-b cell leukemia transformation survival transgene -65-deficient plc 2 culture fraction pi 3k hendrik background slp -65-deficient mice transcription e-btk number factor
8 Most Recent Publications
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PTEN in colorectal cancer: A report on two Cowden syndrome patients
(Article)
Kersseboom, R. Dubbink, H.J. Morreau, H. Wagner, A. Corver, W.E. Tilburg, A.J.P. van Poley, J.W. Leerdam, M.E. van Atmodimedjo, P.N. Laar, I.M.B.H. van de Collee, J.M. Dinjens, W.N.M. |
2012-06-01
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Educational paper - Syndromic forms of primary immunodeficiency
(Article)
Kersseboom, R. Brooks, A.S. Weemaes, C. |
2011-03-01
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Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells
(Article)
Kersseboom, R. Kil, L. Flierman, R. Zee, M. van der Dingjan, G.M. Middendorp, S. Maas, A. Hendriks, R.W. |
2010-09-01
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Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway
(Article)
Ta, T.B.V. Bruijn, M.J.W. de Brugge, P.J. ter Hamburg, J.P. van Diepstraten, H.J.A. Loo, P.F. van Kersseboom, R. Hendriks, R.W. |
2010-02-18
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Control of B Cell Development by the Signaling Proteins Btk and Slp-65
(Doctoral Thesis)
Kersseboom, R. |
2008-03-05
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Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing
(Article)
Gorter, D.J.J. de Beuling, E.A. Kersseboom, R. Middendorp, S. Gils, J.M. van Hendriks, R.W. Pals, S. Spaargaren, M. |
2007-01-01
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Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity
(Article)
Middendorp, S. Zijlstra, A.J.E. Kersseboom, R. Dingjan, G.M. Jumaa, H. Hendriks, R.W. |
2005-01-01
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Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells
(Article)
Kersseboom, R. Middendorp, S. Dingjan, G.M. Dahlenborg, K. Reth, M. Jumaa, H. Hendriks, R.W. |
2003-01-01
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