Dahlenborg, K.

pre-b chain expression b cell development pre-b cells b cells btk-deficient -65 kinase slp -65 usage development tyrosine kinase btk-deficient mice bone marrow receptor surface tyrosine rearrangement level btk mice function receptor editing tumor culture spleen l chain usage bruton immunol marrow protein domain activation result y 223f mutation k 430r mouse fraction btk /slp presence btkact background cytoplasmic activity editing sh 3 domain il -7 stage number x-linked response k 430r mice x-linked agammaglobulinemia splenic b cells bcl -2 l chain rearrangement control transgene locus absence analysis pre-b cell tumors hendrik autophosphorylation marker btke 41k lymphoma b cell population b cell subpopulations www.jem.org pre-bcr splenic il -7 responsiveness november downloaded btk-deficient pre-b cells e 41k flow cytometry 3-83