Jumaa, H.

-65 pre-b slp -65 pre-b cells expression tumor b cells kinase b cell development k 430r protein suppressor tumor suppressor level development function tyrosine pre-bcr tyrosine kinase slp -65 mice btk /slp btk-deficient chain activation btkact b-cell lymphoma pre-b-cell absence il -7 bruton differentiation immunol double-deficient stage activity btk-deficient mice surface k 430r mice pre-b cell tumors result background culture flow cytometric analysis serum figure splenic b cells e 41k immunity calcium receptor phosphorylation spleen k 430r transgene finding slp -65 / adaptor j biol chem number tumor suppressor function btk kinase activity b-cell development splenic kinase-inactive btk plc 2 kinase-inactive defect cycling wild-type presence cytoplasmic pi 3k kinase activity adaptor molecule tumor formation igg 3 levels pathway slp -65. marrow blood