Mulder, E.

receptor binding activity promoter dna binding plasmid androgen expression wild-type ar antagonist transcription promoter activity cho cells luc activity ru 38486 effect interference antiandrogen wild-type library erasmus mc promoter interference assay activation androgen receptor hormone ligand study assay transcription activation protein acetate cyproterone presence domain receptor arl r 1881 ru 23908 reporter result hydroxyflutamide action level receptor expression levels transfected estrogen progesterone element transcriptional trapman j change conformation ligand-binding domain promoter interference agonist mechanism agonistic activity expression levels erasmu transcriptional activity cyproterone acetate brinkmann ar 64 estrogen receptor analysis arl expression plasmid ar expression plasmid mmtv-luc endocrinol absence cotransfected december determination dna-binding luc expression ruiter pe downloaded state wild-type receptor library trapman difference