Terpstra, W.E. http://repub.eur.nl/res/aut/21748/ List of Publications en http://repub.eur.nl/static-eur/img/logo.png RePub, Erasmus University Rotterdam http://repub.eur.nl Primitive progenitor cells in human acute myeloid leukemia : studies in immunodeficient mice and in long-term bone marrow culture (Doctoral Thesis) http://repub.eur.nl/res/pub/18149/ 1997-05-28T00:00:00Z Acute myeloid leukemia is a malignant clonal proliferation of immature hematopoietic cells. Leukemic blasts may express abilities for maturation to a variable degree, which leads to morphological heterogeneity. Generally the transformed leukemic stem cell is committed to the granulocytic lineage. Sometimes a predominance of blast cells from the erythroid or megakaryocytic lineage may be observed. The leukemic transformation may occur at the level of a pluripotent or a less primitive hematopoietic cell. This is apparent from the observation of clonal markers, e.g. unique cytogenetic abnormalities in single versus several blood cell lineages.