Nanda, D.

vector glioma nanda gene therapy therapy tumor expression adenoviral virus adenoviru cancer ig.ad nanda patient study brain treatment pagina imaging gene therapy adenoviral vectors infection replication ig.ad 5e hsv 1-tk herpe level trial brain tumors 123 i-firu hsv 1-tk gene cell lines luciferase animal injection result glioma cells promoter simplex receptor e 3 promoter effect kinase i-firu transfer m.o.i replication-competent ig.ad 5e efficacy toxicity thymidine region glioma cell lines e 3tk 9 l-tk ganciclovir ad 35 ig.adapt.tk fiber sequence suicide uptake phase growth oncolytic administration oncolytic effect luciferase expression survival adenoviruse expression levels tumours e 1 region protein xenograft phase i trial activity tumour intratumoral injection delivery hsv-tk tissue