Vogels, R.

vector ig.ad e 3tk ig.ad 5e tumor replication-competent ig.ad 5e adenoviral glioma virus m.o.i infection adenoviru replication cell lines expression e 3 promoter luciferase cancer ig.adapt.tk effect tumor growth hsv 1-tk treatment region sequence glioma cell lines promoter hsv 1-tk gene e 3 region oncolytic effect brain tumors therapy e 1 region growth adenoviral vectors 87 mg cells e 3luc animal brain luciferase expression injection efficacy intratumoral injection replication-competent adenoviral vectors nonreplicating wtad 5 control expression levels addition level 87 mg xenografts e 1 vector replicationcompetent adenoviral vectors study oncolytic 105 cells /well replication-competent vector e 1-deleted vectors 1-deleted adenovirus death protein life technologies survival combination 7 days luciferase gene replicationcompetent nonreplicating vectors intratumoral xenograft result suicide coding luciferase expression levels pbs.eco-eco /ad hiii fragment herpe pbs.eco-eco 549 cells carcinoma administration