Bout, A.

vector tumor ig.ad luciferase e 3tk adenoviral ig.ad 5e adenoviral vectors expression cancer perfusion virus administration limb perfusion therapy replication-competent ig.ad 5e intratumoral tissue intratumoral injection glioma injection transfer m.o.i luciferase activity infection adenoviru replication promoter study cell lines activity e 3 promoter animal ig.adapt.tk effect tumor growth delivery hsv 1-tk treatment region tumor tissue sequence glioma cell lines hsv 1-tk gene e 3 region organ brain tumors tumor cells oncolytic effect netherland e 1 region growth 87 mg cells e 3luc gene transfer brain gene therapy efficacy luciferase expression result factor replication-competent adenoviral vectors nonreplicating tumor necrosis factor wtad 5 control expression levels addition level hum gene minute protein circuit rotterdam luciferase gene expression luciferase marker gene e 1 vector sarcoma oncolytic adenovirus-mediated gene transfer