Chen, D.J.

protein repair dna-pkc damage figure kinase dsb repair pa 28γ rnf 20 analysis artemi pathway wild-type high-let ir mutation terminus dna damage phosphorylation recombination recruitment 20-rnf assay activity high-let monoubiquitylation chromatin carboxy response proteasome result patient dna damage response histone h 2b monoubiquitylation rnf 20-rnf dna double-strand breaks dsb sites low-let ir dna-dependent protein kinase radiation antibody v 3 cells dna repair coding mre 11 ku 80 double-strand research level binding autophosphorylation low-let processing fragment sirna dna-pkcs kinase activity xrcc 4/ligase iv dna ends rnf 40 effect ku 70/ku expression experiment break end-joining coding joints dna damage sites control histone h 2b damage sites university depletion interaction xrs 6 cells ficient hairpin dna-pk transfected patient id 177 accumulation