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individual sci individuals alternative drug control individuals increase control infusion alternative response phentolamine nicardipine blood recommendation dose adjustment lvr increase pressure concentration level adjustment table plasma nicardipine infusion gene –drug interaction pharmacogenetic allele subject –drug genotype interaction effect phentolamine infusion cord injury nonadrenergic transmission calcium channel blocker heart rate heart injury number dysreflexia study calculation result leg blood flow erasmus mc check inr evidence gene –drug supine volume change norepinephrine leg vasoconstriction maintenance dose angiotensin ii levels cord –injured individuals nonadrenergic patient adrenoceptor vasoconstriction activity blood pressure increase dose transmission hla-b saline j appl physiol ␣- adrenoceptor blockade ␣- adrenoceptor antagonist blocker netherland vkorc cyp 2d cyp 2c report relevance dose adjustments hypertension calcium system vasoconstrictor response
2 Most Recent Publications
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Pharmacogenetics: From bench to byte an update of guidelines
(Article)
Swen, J.J. Nijenhuis, F.C.A.M. te Weide, J. van der Wilffert, B. Deneer, V.H.M. Guchelaar, H.J. Boer, A.G. de Grandia, L. Maitland-van der Zee, A-H. Mulder, H. Rongen, G.A. Schaik, R.H.N. van Schalekamp, T. Touw, D.J. |
2011-05-01
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Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals
(Article)
Groothuis, J.T. Rongen, G.A. Deinum, J. Pickkers, P. Danser, A.H.J. Geurts, A.C.H. Smits, P. Hopman, M.T.E. |
2010-03-01
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