Ahsman, M.J.

patient pharmacokinetic concentration plasma extracorporeal membrane oxygenation clearance sample neonate model effect sildenafil volume study membrane midazolam chapter method distribution extracorporeal variability oxygenation population parameter metabolite blood analyte covariate circuit assay increase figure regimen curve cefotaxime ecmo patients morphine antimicrob agents chemother dose regimens children estimate matrix effects table weight value function water antibiotic infant range matrix sampling solution analysis non-ecmo infusion treatment non-ecmo patients drug assay spectrometry signal accuracy plasma concentrations quantification postnatal age period change nonmem hypertension dose regimen result stability clctx precision exposure cannulation auc 24 table ii clin pharmacokinet desmethylsildenafil netherland