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virus fluenza vaccine vaccination influenza study infection strain mthfr antigenic antibody event response reassortment events h 3n viruses group titer model carrier evolution reassortment person homocysteine iscom level children bmdtb season difference sequence fluenza virus vaccination monkey patient substitution non-carrier syncytial protein nucleotide fluenza virus vaccine table bone mineral density giraf number h 3n virus signi homocysteine levels analysis syncytial virus effect mthfr 677 t-allele treatment value folate epidemic fracture reductase fluenza virus neuraminidase fi rst vaccination mtrr 66 distance ml trees variation netherland smith challenge immunity density hi titer vitamin selection diagnosis iscom /82 vaccine phylogenetic virology ficant pandemic challenge infection antibody response kosakovsky pond