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fibroblast tissue production grave expression patient pdgf-bb ophthalmopathy imatinib mesylate hyaluronan disease imatinib hyaluronan production mesylate thyroid cytokine receptor factor level effect treatment control endocrinol amn 107 antibody proliferation growth activity study pdgf-b il -6 activation tshr expression fi broblasts il -6 production mast cells chapter broblast metab kinase t cells stimulation tgf-b autoantibodie fibroblast proliferation thyroid-associated ophthalmopathy macrophage induction culture protein inhibitor cytokine production ophthalmol 24 hours monocyte pdgf isoforms bahn rs b cells differentiation inhibition immunol clin endocrinol platelet-derived growth factor fibrosis tyrosine rotterdam inflammation result isoform pdgf-ab platelet-derived pdgf-aa interleukin pdgf-a steensel chain netherland process figure target
5 Most Recent Publications
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Graves’ Ophthalmopathy: A Comprehensive Role For Platelet-Derived Growth Factors
(Doctoral Thesis)
Steensel, L. van |
2012-03-07
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Whole orbital tissue culture identifies imatinib mesylate and adalimumab as potential therapeutics for Graves' ophthalmopathy
(Article)
Steensel, L. van Hagen, P.M. van Paridaens, D. Kuijpers, R.W.A.M. Bosch, W.A. van den Drexhage, H.A. Hooijkaas, H. Dik, W.A. |
2011-05-01
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The orbital fibroblast: A key player and target for therapy in Graves' ophthalmopathy
(Article)
Steensel, L. van Dik, W.A. |
2010-08-01
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Platelet-derived growth factor-BB: a stimulus for cytokine production by orbital fibroblasts in Graves' ophthalmopathy.
(Article)
Steensel, L. van Paridaens, D. Dingjan, G.M. Daele, P.L.A. van Hagen, P.M. van Kuijpers, R.W.A.M. Bosch, W.A. van den Drexhage, H.A. Hooijkaas, H. Dik, W.A. |
2010-01-01
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Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: A potential treatment for Graves' ophthalmopathy
(Article)
Steensel, L. van Paridaens, D. Schrijver, B. Dingjan, G.M. Daele, P.L.A. van Hagen, P.M. van Bosch, W.A. van den Drexhage, H.A. Hooijkaas, H. Dik, W.A. |
2009-12-01
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