Hunger, S.P.

asparaginase children erwinia asparaginase study patient leukemia erwinia lymphoblastic leukemia treatment group cancer lymphoblastic toxicitie therapy agent regimen vaccination grade coli asparaginase childhood trial infection chemotherapy toxicity varicella result induction vzv vaccination approach blood hospital vzv infection level protocol asparagine antibody grade 3 toxicities backbone oncology novel grade 3 peg-asparaginase pediatr blood cancer phase outcome pediatr death finition survival novel agent activity center department administration hypersensitivity disease j clin oncol university backbone regimen depletion second-line varicella vaccination reinduction l-asparaginase preparation recommendation 4 toxicities adult vaccine reaction month delay table pediatrics asparagine depletion novel agent x lymphoblastic leukemia /pieters enzyme serum study groups