Kemperman, P.M.J.H.

caspase level -14 mutation eczema caspase -14 atopic allergy filaggrin atopic dermatitis patient study children raman caspase -14à/à mice genotype onset dermatiti dermatol flg mutations hr-ige-f factor protein barrier stratum stratum corneum -14à/à subject severity spectra figure month infant cleavage analysis speci corneum immunol nmf levels raman spectra number atopic eczema value laggrin degradation moderate-to-severe ad flg genotype transepidermal water loss water sensitization peanut flg degradation fi laggrin hyperlinearity concentration epidermal profilaggrin association germany group ige-fa flg mutation status eczema severity population function tyrosine nmf level scorad carrier ige food sensitization caspase -14à/à skin measurement raman spectroscopy fragment layer frequency table history result peptide