Wouters, J.M.G.W.

polymorphism patient disease arthritis study control treatment carrier association ra patients gr polymorphisms therapy glucocorticoid factor allele severity receptor susceptibility netherland genotype disease severity 22/23ek result glucocorticoid receptor gene table group villonodular synovitis rotterdam synovial number lamberts sw n 363 dmard frequency response 20 weeks arthritis research synoviti control group rheum effect anti-tnfa reference sensitivity erasmus mc department koper jw tissue expression rheumatology level anti-tnfa therapy gc sensitivity analysis research tumor necrosis factor blood 9 b polymorphism interleukin jong fh cytokine macrophage villonodular disease activity gc resistance infliximab medication emont brinkmann ao erosion bonferroni correction non-carrier tnfa -238 polymorphism gr gene ra susceptibility anti-tnf pathogenesis 22/23ek polymorphism population necrosis