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study pregnancy blood pressure reference smoking children association weight month growth level birth blood pressure c-reactive protein levels breastfeeding protein c-reactive birth weight generation r study model structure childhood body mass index measurement diameter disease development 24 months hypertension trimester effect child diastolic blood pressure type 2 diabetes mother cohort aortic root diameter atrial diameter table infant result chapter difference steegers ea generation index trend heart change obesity characteristic c-reactive protein factor <0.01 value outcome duration health adult regression height diastolic aortic systolic 6 years cohort study jaddoe risk factors regression models jaddoe vw adulthood status diabetes information function breastfed effect estimates analyses nurse