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gh treatment treatment group score height level growth children height sd score discontinuation insulin study 6 months endocrinol hormone syndrome effect subject metab gh-treated sga subjects turner syndrome glucose sga controls control dosage turner adult month growth hormone treatment gh groups growth hormone gh-treated fh sd score dutch increase 6.5 yr behavior igf-i insulin levels insulin sensitivity gh dosage groups gh dosage group c problem result risk factors netherland sd score estrogen circumference fasting change serum cholesterol igfbp -3 levels systolic sd-score hospital difference pretreatment value hdl-c model estrogen treatment 4 yr post evaluation sga subjects blood pareren s-score diastolic table control group lipid adult height 6.5 waist circumference ldl-c factor 0.001