Ruijs, M.W.G.

cancer family mutation breast cancer breast syndrome partner germline surveillance netherland study distress patient member carrier tumour signi ficantly level tumours table criteria family members advice individual tumor li-fraumeni syndrome genetic signi analysis testing diagnosis li-fraumeni risk family members chompret criteria sarcoma history chompret spouse support worry number department centre score disease attitude dutch genet bene fits ficantly children scale brain fi rst sample family history lfl criteria amsterdam phenotype carcinoma screening women index tp 53 gene chek 2 respondent sequence fraumeni jf jr tp 53-positive families chek 2 gene c-revised .1100delc variable control brain tumour sf -36 scales questionnaire lfs family members vhl family members intron