Zuijlen, C. van

paclitaxel plasma docetaxel pharmacokinetic cancer patient study concentration blood r 101933 level infusion cremophor resistance cremophor el p-glycoprotein phase multidrug verweij j r 1 01933 disposition treatment effect combination model tumor chapter agent multidrug resistance anticancer protein toxicity administration distribution stoter g cycle expression sample sparreboom doxorubicin value vehicle interaction beijnen jh verweij ratio nooter k oncol dose levels result inhibition formulation function inhibitor dose level activity compound anticancer drugs parameter fraction nonlinear analysis increase elimination taxane metabolite table tween micelle phase i study human nooter clearance plasma concentrations binding stoter chemotherapy tween 80 tissue method