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patient virus cornea herpe simplex keratitis disease gm-csf genotype herpetic acyclovir study infection hk patients graft herpetic keratitis neutrophils table dna load herpes simplex virus cytokine factor neutrophil tissue strain survival ophthalmol treatment acyclovir-resistant mutation epithelial resistance prevalence stromal herpetic stromal keratitis expression chapter acvr hsv sequential protein assay therapy il -17 control culture sequence number variant virol susceptibility graft survival non-hk patients donor -17 effect transplantation medium tk gene thymidine immunol result polymorphism erasmus university rotterdam group kinase tk protein non-hk latency response osterhaus ad secretion reactivation cell types association acyclovir-resistant hsv epithelial cells remeijer recurrence figure region
