Mihaescu, R.

disease study reclassi fication fication prediction reclassi type 2 diabetes value alzheimer model individual polymorphism diabetes testing disease risk frequency cutoff 18 polymorphisms variant body mass index group research factor population genotype cutoff value health risk factors sensitivity percentage reclassi fication measures threshold genomic figure score cutoff values measure diagnosis improvement rotterdam reclassi fication improvement dementia / translational genomics risk predictions category mihaescu distribution number treatment tcf 7l netherland association genet allele curve effect impact rotterdam study erasmus university rotterdam simulation study analyses application genetic alzheimer disease university risk models risk prediction risk scores simulation van duijn cm medicine translation research patient genome-wide control example translational index erasmu specificity