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activity serum inhibitor pruritu figure patient atx activity atx –abp level autotaxin choline release assay reaction assay cholestatic boronic concentration solution molecule ic 50 control labelling receptor probe lysophosphatidic lysophosphatidic acid 37 8 c choline netherland sample compound inhibition ic 50 values cholestatic patients boronic acid protein cancer –liver pancreas lipid reaction mixture disease cholestasi release biliary value screening mixture plasma effect isoform atx inhibitors enzyme 5 μ m moolenaar bis-pnpp bis-pnpp assay boronic acids liver carboxylic acid percentage inhibition factor - opioid activity moiety optimization intensity chemical result scheme cholestatic disorders thiazolidinedione opioid intrahepatic cholestasis group meeteren histamine substance carboxylic correlation product activity-based cpf 4 assay
3 Most Recent Publications
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Development of an Activity-Based Probe for Autotaxin
(Article)
Cavalli, S. Houben, A.J.S. Albers, H.M.H.G. Tilburg, E.W. van Ru, A. de Aoki, J. Veelen, P. van Moolenaar, W.H. Ovaa, H. |
2010-11-02
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Lysophosphatidic acid is a potential mediator of cholestatic pruritus
(Article)
Kremer, A.E. Martens, J.J.W.W. Geenes, V.L. Williamson, C. Moolenaar, W.H. Beuers, U. Oude Elferink, R.P.J. Kulik, W. Rueff, F. Kuiper, E.M.M. Buuren, H.R. van Erpecum, K.J. van Kondrackiene, J. Prieto, J. Rust, C. |
2010-09-01
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Discovery and optimization of boronic acid based inhibitors of Autotaxin
(Article)
Albers, H.M.H.G. Meeteren, L.A. van Egan, D.A. Tilburg, E.W. van Moolenaar, W.H. Ovaa, H. |
2010-07-08
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