Berkowska, M.A.

b-cell memory b cells rearrangement memory b cells subset expression response figure patient memory b-cell subsets blood immunol repertoire level thesis analysis 10/22/2012 approved.indd m.berkowska il -7 study control frequency replication history plasma immunoglobulin number plasma cells recombination 27-iga antigen chain differentiation population receptor j exp med antibody region 27+iga generation mutation bone marrow ppbl cells cd 127− cells locus protein pre-b pre-b cells pro-b proliferation cd 127ϫ cells marrow result development effector j immunol maturation pathway signal gc b cells replication 127+ history b-lineage difference immunocompetent nbs patients cd 127+ cells immunocompetent b-cell repertoire b-lineage cells shm levels factor 27+igm cd 127ϩ cells cd 27+iga value origin 27-ige selection