Nosé, V.

liver hepatic marimastat animal hepatic steatosis group injury fibrosis level steatosi hf diet figure insulin c 57bl mice intake treatment hepatic injury liver sections weight control insulin resistance study effect matrix metalloproteinase vehicle inhibition section inflammation lf diet obesity content activity tissue 9 weeks serum alt levels expression liver fibrosis / metabolism necrosis tnf-a liver injury non-fibrotic control group carbon tetrachloride insulin sensitivity resistance model result disease transcript fibrogenesi serum ccl 4 inhibitor rhf-p analysis collagen adipose tissue development administration libitum calorie liver disease mmp-inhibition metabolism boston nafld srebp tumor necrosis factor marimastat treatment lf mice ccl 4 administration receptor sensitivity control group meijer beth israel deaconess table hepatic transcript levels activation