Verhoeven, G.T.

patient study airway effect respir inhaled asthma disease treatment methacholine group curve smoker placebo fev 1 copd patients function pc 20 smoking value table number fluticasone glucocorticoid month inflammation change correlation lung function histamine result level hyperresponsivenes therapy decline placebo group subject index laf cells biopsy bronchitis 6 months plateau propionate analysis expression fluticasone propionate responsiveness netherland response emphysema production biopsy specimens dendritic cells chest eosinophil airflow concentration cigarette baseline trial reactivity obstruction inhaled glucocorticoids dendritic airways inflammation lavage fluid relationship macrophage difference tuberculosis marker inhaled glucocorticoid therapy sputum airway responsiveness mechanism alveolar bal fluid inhaled budesonide