Incardona, F.

sequence resistance treatment patient mutation indinavir model system score landscape fi tness evolution fi tness landscape genotypic population therapy virological fi tness landscapes hivdb signi ficantly parameter baseline genotypic susceptibility score group failure subtype interpretation indinavir treatment pressure signi interpretation systems susceptibility response virological failure sequence data pressure <0.01 epistatic interactions interaction outcome table prediction fcros treatment failure follow-up flongd flongt odds ratios ficantly analysis value change epistatic flongp sangeda genotypic susceptibility scores fi tness function number fi tness values barrier / infection network -02 study suppression evaluation fl parameters p-value vandamme regression algorithm point time points fi tness threshold deforche load measurement 0.65 -03 protease comparison correlation