Rodin, A.S.

statin study abcb 1 slco 1b haplotype index date control patient interaction response abcb 1 gene allele index group effect genotype ischemic heart disease slco 1b gene pharmacogenetic transporter variant pharmacogenomic variability pharmacy records participant carrier research calcium channel blockers pharmacy polymorphism statin treatment pharmacokinetic 0.39 record science 0.72 cohort future association simvastatin article subject treatment atorvastatin population 0.37 exposure lipid response statin therapy figure table 0.38 0.41 0.45 disease effectiveness infarction abcb 1 genes 3435 c >t pharmacol peter frequency 521 t >c slco 1b haplotypes slco 1b polymorphism klungel gene –treatment interactions 0.43 0.42 hypercholesterolemic rodin status risk reduction region niemi m rs 3789244 q-value 0.32 0.33 reference group