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training laparoscopic skill study adjustment fio 2 adjustments simulator group level spo 2 syringe trainee light resident performance illumination infusion extender number participant fl ow-rate variability method score wound fio 2 classi fication method classi fication surgery patient fio 2 adjustment figure alarm limits step size endosc infant assessment alarm procedure attempt criteria volume result instrument surgeon simulation range laparoscopic surgery device iv administration depth van der eijk netherland variability therapy preprogrammed vr simulator iv therapy limit experience ficiency oxygen distribution model effect delivery length displacement tubing signi control delft analysis table competition novice design speci lowsat 0.000