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t-all patient expression leukemia lymphoblastic leukemia figure lymphoblastic cluster deletion identi fied t-cell level fication analysis mir -196b mef 2c t-all cases study identi -196b set-nup classi sample blood translocation fusion set-nup 214 subgroups tlx 3 mutation region subtype abnormality cancer precursor table lmo 2 rearrangement probe b-all notch outcome 2-1 cohort hoxa cluster activation nkx 2-1 mll-rearranged chromosomal number development bcr –abl signi chromosome bcr –abl disease genomic group speci loucy precursor b-all cases protein children netherland treatment oncogene hoxa genes calm-af hoxa 9 classi fication hoxa cluster genes bcr –abl cases array-cgh microarray coall value t-all patients notch 1 mutations control fish analysis breakpoint
7 Most Recent Publications
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Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
(Article)
Homminga, I. Pieters, R. Vlierberghe, P. van Ferrando, A.A. Cayuela, J.M. Verhaaf, B. Beverloo, H.B. Horstmann, M. Haas, V. de Wiekmeijer, A.-S. Pike-Overzet, K. Staal, F.J.T. Langerak, A.W. Laat, W.L. de Soulier, J. Sigaux, F. Meijerink, J.P.P. Rooi, J.J. de Stubbs, A. Verstegen, M.M.A. Vuerhard, M.J. Buijs-Gladdines, J.G.C.A.M. Kooi, C. Klous, P. |
2011-04-12
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Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia
(Article)
Schotte, D. Lange-Turenhout, E.A.M. Stumpel, D.J.P.M. Stam, R.W. Buijs-Gladdines, J.G.C.A.M. |
2010-10-01
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A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study
(Article)
Boer, M.L. den Slegtenhorst, M. van Horstmann, M.A. Janka-Schaub, G.E. Kamps, W.A. Evans, W.E. Pieters, R. Menezes, R.X. de Cheok, M.H. Buijs-Gladdines, J.G.C.A.M. Peters, S.T. Zutven, L.J.C.M. van Beverloo, H.B. Spek, P.J. van der Escherich, G. |
2009-02-01
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Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia
(Article)
Vlierberghe, P. van Beverloo, H.B. Buijs-Gladdines, J.G.C.A.M. Wering, E.R. van Horstmann, M. Pieters, R. Meijerink, J.P.P. |
2008-07-01
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The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia
(Article)
Vlierberghe, P. van Grotel, M. van Buijs-Gladdines, J.G.C.A.M. Horstmann, M.A. Wering, E.R. van Soulier, J. Pieters, R. Meijerink, J.P.P. Tchinda, J. Lee, C. Beverloo, H.B. Spek, P.J. van der Stubbs, A. Cools, J. Nagata, K. Fornerod, M.W.J. |
2008-05-01
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Cooperative genetic defects in TLX3 rearranged pediatric T-ALL
(Article)
Vlierberghe, P. van Homminga, I. Zuurbier, L. Buijs-Gladdines, J.G.C.A.M. Wering, E.R. van Horstmann, M.A. Beverloo, H.B. Pieters, R. Meijerink, J.P.P. |
2008-04-01
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Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences
(Article)
Grotel, M. van Meijerink, J.P.P. Veerman, A.J.P. Noesel, M.M. van Pieters, R. Wering, E.R. van Langerak, A.W. Beverloo, H.B. Buijs-Gladdines, J.G.C.A.M. Burger, N.B. Passier, M.M. Lieshout, E.M.M. van Kamps, W.A. |
2008-01-01
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