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figure s-phase transition erythroid pu .1 0 cells cycle differentiation expression s-phase progression 1 transition chromatin progression experiment 1 cells cell cycle liver p 57kip b-globin 57kip control downregulation subset aphidicolin panel gata -2 dnase level erythroid differentiation b-globin lcr 2/2 dnase i hypersensitivity epor 2/2 dna demethylation cfu-e lineage replication arrest locus pu .1 expression cd 71 upregulation induction figure 3 commitment number erythroid-specific genes effect upregulation transcriptional activation cell cycle clock pu .1 downregulation cell cycle exit progenitors dna replication transduced onset presence program erythroid differentiation program methylation coordinate function b-globin locus change biology control cells issue september analysis profile hypersensitivity demethylation volume block antibody vector www.plosbiology.org hematopoietic switch
1 Most Recent Publications
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A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression
(Article)
Pop, R. Shearstone, J.R. Shen, Q. Liu, Y. Hallstrom, K. Koulnis, M. Gribnau, J.H. Socolovsky, M. |
2010-09-01
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