Langeveld, S.C.L.

patient blood number cancer level t cells therapy treatment blood samples sample t-cell lymphocytes cytokine infusion flow cytometry immunogene therapy detection plasma receptor cytometry assay lamer rcc cells method panel production transduced immunol cycle percentage result cytokine production variation patient 2 rcc patients t lymphocytes patient 1 tumor transduced t cells activity liver toxicity clone immunogene patient 3 function transfer cell cancer rosenberg staining autologou administration gene-modified t cells liver g 250 mab nuh 821 cells metastatic plasma cytokine levels cytometric chain sensitivity 0.1 fg cytolysis gene-modified target willemsen study dudley cell transfer therapy control il -10 nuh 82 mab expression toxicity k 562 targets event plasma ifn il -2 administrations polymerase chain reaction flow cytometric method interleukin