Ta, T.B.V.

pre-b chain expression leukemia tumor pre-b cells figure recombination slp 65 transformation protein b cells 65-deficient development pre-bcr b cell development immunol pathway receptor pro-b region rearrangement transcription b-cell chapter btk /slp antigen mouse igh.te germline jumaa h level activation 19arf kinase stage proliferation model il -7r result c-myc analysis allele segment pro-b cells suppressor hendriks rw activity igh.t reth m immunoglobulin differentiation pre-b cell leukemia locus usage function transgene survival jumaa il -7 surface panel fraction factor presence hendrik pre-b cell tumors tyrosine oncogenic mutation dingjan gm antibody repair slp -65 lymphoma pre-b cell receptor ficient slp 65-deficient mice -65 65-/-