Haan, A.B.

leukemia pre-b ficient chain expression 65-de transformation pre-b cells 3-83 recombination double-de pre-b-cell receptor slp 65 activity tumor b cells development protein figure il -7r 3-83 md b-cell pre-bcr background immunol c-myc btk /slp jumaa h rag 1 reth m pro-b-cell stage dna-pkcs-de ficient mice panel fl ow cytometry rearrangement transgene jumaa autoreactive dot plots mouse surface slp 65-de editing b-cell development number stage receptor editing dna-pkc leukemia formation slp 65 expression slp 65-de leukemias erasmus mc rotterdam proliferation cycling pre-b cells 3-83 md transgene level kinase m h chain 3-83 md tg 3-83 md bcr dingjan gm igh chain pathway ficiency rag proteins c-myc expression formation nding fi nding lymphoblastic leukemia suppressor hendrik analysis nemazee immunity 54-1 pro-b-cell fraction function