Zeneyedpour, L.

peptide sample sequence antibody immunoglobulin antigen cdr peptides adalimumab anti-dnp analysis sequencing serum concentration chain intensity number region database spectrometry result affinity germline feature amount orbitrap group approach protein spectra purification light chain cdr 3 biomarker disease preimmune sera beads addition light erasmus mc dataset biomarker discovery method gel plugs immunization igg pool animal abundance immunoglobulin peptides method mutation mass spectrometry serum samples proteomic fragment fragmentation column search signal affinity purification treatment response detection background melon alignment preimmune anti-dnp antibody ighv 1 peptides binding cdr 3 peptides 2 μ g melon gel table immunoglobulin molecule antibody sequences proteomic analysis measurement room temperature origin nanolc analyses